BIO Essay Example | Topics and Well Written Essays - 250 words - 6

BIO - Essay Example In particular, I led a group of officers to survey and install security application. In that accord, I completed a site survey for a new secure yard for FSR and STSs. Using my technical expertise, I was able to restore a malfunctioning Pick to Light (PLT) System. Specifically, the system had lost its audio, and I was able to detect the defect through troubleshooting using a particular program and restore it to its previous functionality. In the absence of a video for the TOC users, I relied on my knowledge and skills to replace four Video Matroxs to restore the videos, and the TOC operators used them. My efforts and expertise has not gone unnoticed since I received a TOC coin and awarded for excellence work performance. Specifically, this happened while working as a TDY to Basrah where I successfully cleared 35 alarms in the TR room within two minutes of customer calls. In addition, I installed four TV monitors in the TOC for better security coverage of the embassy compound for customers. In short, this illustrates my incredible knowledge, expertise, and experience in the technology-enhanced security

Judaism Research Paper Example | Topics and Well Written Essays - 1250 words - 1

Judaism - Research Paper Example Even though evidence cannot be provided for the existence of the one or may Supreme beings, there is evidence for the power of religion. There are numerous religions across the globe. However, the most distinct one are Islam, Judaism, Christianity, Buddhism, and Hinduism. These religions have symbols, narratives, and sacred histories whose purpose is to explain the meaning and origin of life. In the same way, from their beliefs about human nature, the people may derive ethics, morality, and religious laws. The religions have the clergy, organised behaviours, Holy Scriptures, holy places, and a definition of what makes up adherence. The practice of religion may also include things like commemoration, feats, festivals, prayer, sacrifices, sermons, and rituals. Besides that, they also have myths, funerary services, and other aspects of the human culture. Drawing on a variety of sources, the paper will address Judaism history and the present practice. It has been evidenced that Judaism is among the oldest religions on earth that exist until today. Its history, traditions, and beliefs are recorded in the Hebrew Bible. Judaism is a religious tradition that dates back to about 4,000 years ago, and is rooted in the eastern region of Canaan. Canaan is the biblical name of the region between River Jordan and the Mediterranean. This is the equivalent of the current Palestinian and Israel territories (Shahak, 1994). This was during the Bronze Age in the Middle East. Even though the Jewish calendar dates back to more than five thousand years ago, various scholars argue that the commencement of the Judaism faith is linked to the Israelites and their forefather Abraham. This is estimated to be around 164 B.C.E. The beliefs and practices of the classical Judaism did not emerge until the 1st century (Schachter-Shalomi & Segel, 2013). In this regard, Judaism

BIO Essay Example | Topics and Well Written Essays - 250 words - 6

BIO - Essay Example In particular, I led a group of officers to survey and install security application. In that accord, I completed a site survey for a new secure yard for FSR and STSs. Using my technical expertise, I was able to restore a malfunctioning Pick to Light (PLT) System. Specifically, the system had lost its audio, and I was able to detect the defect through troubleshooting using a particular program and restore it to its previous functionality. In the absence of a video for the TOC users, I relied on my knowledge and skills to replace four Video Matroxs to restore the videos, and the TOC operators used them. My efforts and expertise has not gone unnoticed since I received a TOC coin and awarded for excellence work performance. Specifically, this happened while working as a TDY to Basrah where I successfully cleared 35 alarms in the TR room within two minutes of customer calls. In addition, I installed four TV monitors in the TOC for better security coverage of the embassy compound for customers. In short, this illustrates my incredible knowledge, expertise, and experience in the technology-enhanced security

Reaction to Everyday Use Essay Example for Free

Reaction to Everyday Use Essay Everyday Use is a short story written by Alice Walker about a family of three, Mama, the narrator, Maggie her youngest daughter, and Dee, her eldest daughter. Both daughters are completely different, Maggie is a simpler person and Dee is high maintenance. Dee has always the home she was brought up in and everything to do with her childhood. She always wanted more and Mama gave her the best she could. One day, years after Dee has gone off to college, she returns to visit Mama and Maggie’s new home (the other had been burnt down when Dee was still living with them), and she brings along a man, possibly her husband. When Dee returns she has changed her name and has come hoping to retrieve certain family heirlooms. Walker uses different literary tools to tell this story in a way that makes the audience think about what she is trying to tell the audience. Strategy The main literary strategy Walker uses in the writing of Everyday Use are irony and symbolism. Mama and Maggie value the quilts discussed in the story, not as folk art, instead for what they are intended to be used for, a source of warmth. Mama would rather give Maggie the quilts and let her put these quilts to use even though they may end up ruined because she knows that she is the one that will appreciate and love the quilts the most. Dee wants to in a sense save the quilts from the harm that she is sure that her sister, whom she seems to think is intelligently inferior will ruin but she does not understand the true value and worth of these quilts. Dee’s sudden interest in her heritage and want to embrace different objects from her family’s past is obviously seen by her mother as empty. In Mama’s eyes the best way to keep the quilts and the love and care that comes with them in the family is to hand them over to Maggie, even if it means them possibly being damaged or worse yet, destroyed. This is the irony in the story. Many would think that preserving the quilts is the only respectful way of keeping the spirit of their family alive, but instead Mama sees deeper than that, she sees in actuality the best way to keep the spirit of their family alive is to put them to use so that more memories can be connected to them. Using them in daily life is a way to keep the family history and spirit alive, and to even add onto it. Theme The consistent theme of Alice Walker’s â€Å"Everyday Use† is appreciating the past, and one’s family. This theme was one that I found I could identify with greatly along with certain aspects of the story. The author skillfully tells us the story of two sisters, Dee, and Maggie, to prove her point. Dee comes home with a new contemporary identity tied to her African heritage, which she believes white men and women have tried to take away from her. She now embraces this African heritage and sees it as an important part of her. She scornfully asks Mama (the narrator) to not address her by the name her mother gave her, Dee, but to instead call her Wangero, assumed to be a name from her African herritage: What happened to Dee? I wanted to know. Shes dead, Wangero (Dee) said. I couldnt bear it any longer, being named after the people who oppress me. Wangero (Dee) assumes and argues with her mother that she has been named \ after a white man or woman. Mama attempts to convince her that her name was not given to her by a white man or woman but that she was named after her grandmother. Dee resists what her mother has told her and insists that if she were to follow the line that it would go back to a white man or woman. Maggie, is unashamed of her past, she actually embraces it. She has always loved the quilts that her mother and aunt made from clothing that her grandmother had pieced. This section of the story is the prime difference between the sisters is revealed: Dee would like to use the quilts as pieces of artwork for her own home because it is something that would be stylish and argues with her mother that Maggie would be backward enough to put them to everyday use. Dee says this as if it were a bad thing to use the quilts as they were intended to be used but Mama believes that the everyday use, is the best way to value the past, to keep the spirit of the family going and not putting the items up for display as if they were in a museum or separating oneself from his or her family. This is something that I can identify with. When I was younger my great-grandmother had always crocheted afghans for each of her children, grandchildren and great-grandchildren. My cousins had when we were little looked down at these beautiful afghans and wanted instead store bought blankets. I treasured the afghan that my great grandmother had made me and used it often. When we were older, and she had passed away, my one cousin was going through a phase similar to Dee’s, she was suddenly very interested in our family history, and she now wanted the last afghan that my great grandmother made. She ended up being the one to receive the afghan because I did not feel like fighting over it. I did not want to receive it with a fight because I knew that it would tarnish the meaning for me but I always found it interesting how she changed her mind once became, for lack of a better word, â€Å"cool† to embrace family history and to like handmade items. Active and Responsive Reading While reading Everyday Use one inference that I made was that the story was set in the early 1970s. I made this inference from the way Mamma, the narrator, described Dee in the present day. I thought that the dress, accessories, and hair style Dee was described to have seemed to match up to fashion from the early 1970s. Dee is a vain, hypocritical, and condescending individual, this was my impression from my first reading of the story and after reading it twice more, I found that my impression of Dee did not change from my first reading. Mamma did the best she could for Dee as she grew up. Dee always despised the house they lived in and never saw the house that was built after the fire until she visited. Mamma and their church raised money so that Dee could get a higher education and go off to college. Dee uses her education as a way to look down on her mother and sister. She does not understand why they will not better themselves as she has. In this visit she begins asking her mother for things that she had never wanted before and looked down at. She now wants these items not as reminders of her family but more as pieces of art. Two of these items were quilts made by Grandma Dee. In the past when offered these, she had told her mother that the quilts were â€Å"too old-fashioned, out of style†. Now she thinks that they would make beautiful pieces Alice Walker writes this story I think for every family and every person in a family. In a world where people are consumed with art, fashion, and style, I think she is reminding us that there is more to some items than art, fashion, and style. Many times we think the only way to appreciate something is to frame it or put it up for display and not put it to everyday use in fear of ruining it but Walker uses this story to show us that there is more to appreciating something than just displaying it. Sometimes to best appreciate a piece of ones heritage through an heirloom you should use it for its intended purpose. In conclusion Walker teaches us a lesson about family and keeping the spirit and story of our family alive by not merely displaying our heirlooms but putting them to use. She uses irony to help tell her story and support her theme. Walker chooses a story that people can relate to and learn from.

Computational Chemistry for Drug Discovery

Computational Chemistry for Drug Discovery Computer Chemistry Computational chemistry is a branch of chemistry that uses computers to assist in solving chemical problems. It uses the results of theoretical chemistry, incorporated into efficient programs, to calculate the structures of molecules and solids. In theoritcal chemistry, chemists, physicist and mathematics develop algorithms and computer programs to predict atomic and molecular properties and reaction paths for chemical reactions. Computational chemists, in contrast, may simply apply existing computer programs and methodologies to specify chemical question. There are two different aspects to computational chemistry. Computational studies can be carried out in order to find a starting point for a laboratory synthesis, or to assist in understanding experimental data, such as the position and source of spectroscopic peaks. Computational studies can be used to predict the possibility of so far entirely unknown molecules or to explore reaction mechanisms that are not readily studied by experimental means. Computer-aided drug discovery/design methods have played a major role in the development of therapeutically important small molecules for over 2-3 decades [133]. Over the past couple of decades, many powerful standalone tools for computer-aided drug discovery have been developed [134]. In silico metabolism After adopting combinatorial chemistry and high throughput biological screening in the past couple of decades, the pharmaceutical industry generated a large collection of potent and selective compounds for numerous targets. However, to become an optimal drug, in addition to potency and selectivity, a compound must have appropriate ADME (absorption, distribution, metabolism and excreation), safety and developability characteristics. Relaying solely on potency in the early stage of drug discovery can result in disproportionate attrition after clinical candidate selection contributing to the exorbitant costs of discovering and developing drugs. Only about one in ten of those diligently chosen, highly potent and selective candidates that enter development reach the market often due to inadequate ADME properties. Therefore, it is extremely important to consider the ADME characteristics of compounds earlier in the discovery process to wager bets on compounds that have a greater potential t o survive the development and clinical trail stage of drug development. Increasing the odds of success to one in five (instead of ten) would reduce the total cost of bringing a new therapeutic to the market by 33%. Experimental determination of ADME and pharmacokinetic (PK) characteristics is both expensive and time consuming, and is not practical for large numbers of compounds, especially when the pharmaceutical industry is under severe pressure to cut costs and improve efficiency. The Price tag to support various ongoing discovery projects in pharmaceutical company for synthesis and high throughput measurement of permeability, solubility, metabolic stability and acute toxicity can run into millions of dollars. Therefore, much attention is being focused on the application of in silico screens to reliability predict ADME attributes solely from molecular structure. In silico prediction of ADME properties will not only reduce cost and development cycle times by wisely directing resources to essential experimental testing, but also bring forward their consideration earlier at the lead generation stage when compounds are being synthesized and tested almost exclusively to meet pharmacological target potency levels. At the cost of experimental results indicated above, a mere 10-20 % reduction in high throughput experimental measurement of permeability, solubility, metabolic stability, acute toxicity through the use of in silico screens can lead to significant savings. Further, application of in silico screens offers an ideal ‘fail-early-fail-cheaply’ strategy for drug discovery because their application requires nothing more than inputting the basic structural information of a compoun d into a validation model. Metabolic Stability Measurement in Drug Discovery At most major pharmaceutical companies, metabolic stability assays are conducted at the first investigation into the metabolism of a compound. These in vitro assays generally utilize liver microsomes and/or hepatocytes to furnish important information about the rate and/or metabolism. In vitro metabolic studies are important in optimizing pharmacokinetic properties such as in vivo half life, maximum concentration and systemic exposure, because rapid metabolism is often a key factor contributing to poor exposure. The metabolic stability data is helpful for ranking molecules with respect to their ability to resist metabolism. Though high-throughput automated metabolic stability assay systems have been developed by the major pharmaceutical companies, screening a large number of compounds is still intensive. Thus, in silico prediction of metabolic stability can be used to rationalize experimental testing and have significant resources. Further, these models allow for prediction of metabolic stability for virtual libraries, thus bringing forwarded their consideration earlier to hit-to-lead stage. In silico Models for Metabolism Studies There are several types of in silico tools available for investigations into metabolism. These include knowledge based systems (metabolism databases) rules based or expert systems and quantity structure properties relationship (QSPR) and enzyme structure modeling systems. At its simplest, the partition coefficients, Log P (or its computed equivalent), of a drug in the n-octanol-water system has been shown to loosely correlate with the metabolic stability of a compound. As in silico calculations of Log P values have become readily available, they are being implemented in many of the current metabolism prediction packages. The earliest in silico metabolism tools were the metabolic reaction databases. In principle, these are databases with the published metabolic reactions and structure of parent compounds and their metabolites. Some of these allow creation of corporate metabolic databases as well. In most cases, these databases can be searched for specific biotransformation (by structure and substructure), biotransformation keywords, and by other user-defined fileds. The key advantage of this knowledge based in silico systems is that they include detailed metabolism findings and original references. Prediction of Metabolites The above mentioned knowledge based systems provided the groundwork for the development of rules based in silico predictors of metabolites, also called expert systems. Commercial rules based programs such as METEOR, META and MetabolExpert iteratively interrogate the chemical bonds of a molecule and apply programmed biotransformation rules in a predetermined hierarchy. As one can imagine, without means of terminating the metabolism tree a very large numbers of metabolites will be generated of predicted. Several of these programs allow the user to specify the number of levels of biotransformation or may use a LogP calculation to terminate the biotransformation process. Prediction of Sites of Metabolism The mechanism of oxidation by CYPs is though to be constant across all CUPS. One of the most important steps in the oxidation of drugs (by CYPs) is the ability of the perferyl oxy species (FeO+) to carry out a one-electron oxidation through the abstraction of hydrogen atoms. In silico packages such as Admensa, COMPACT and Metasite calculate the likehood of abstracting a hydrogen atom from all sites on a molecule, and then quantify which sites are most likely to be oxidized. The greatest advantage of these types of predictions is the ability to quantify the most likely major â€Å"hot spots† on the molecule. Prediction of Substrate Binding The ability of a molecule to properly dock on the active site of enzyme plays a major role in accurately determining the site(s) of metabolism on a molecule. Therefore, modeling of the P450 active sites has long been a goal for metabolism prediction. Some of the first attempts to model the active site of metabolizing enzymes used pharmacophore, site directed mutagenesis, and protein homology. Using homology models built from bacterial and mammalian P450s, in silico studies of docking potential substrates into the active site have been performed with mixed success. Now that the crystal structure for human CYP3A4, CYP2C9, CYP2C8 and CYP2A6 are available docking experiment with these models should more reliably predict the sites of metabolism on a molecule that the predictions form the homology models. Prediction of Metabolic Inhibition One of the causes of drug-drug interactions is the inhibition of metabolic pathways. Enzyme inhibition by a drug leads to a decrease in metabolism and intrinsic clearances, and an alteration in pharmacokinetics of a co-administered drug. Any knowledge around the potential of drug-drug interactions is useful for a quantitative assessment of the ability a new molecular entity to inhibit the metabolism of another drug. In silico methods to predict drug-drug interactions are mostly limited to competitive inhibitors because they rely primarily on the binding models in the used as templates with alignment and orientation of core structure in an active site. However, the quality of prediction depends on the structural similarity to the molecules that were used to build the model. Inhibitors of CYP2D6 and CYP2C9 have been predicted using the CoMFA method. For inhibitors of CYP3A4, CYP2C9 and CYP2D6, methods such as CATALYST and GRIND have been used to reduce the bias in the alignment of inhibitors. Prediction of Enzyme Induction The induction of drug metabolizing enzymes is an additional way in which co-administered drugs can affect the clearance and pharmacokinetics of a given drug. Induction or increased expression of the drug metabolizing enzymes leads to an increase in the rate of metabolism and ultimately, to increase intrinsic clearance. Therefore, enzyme induction leads to decreased drug exposure which may results in therapeutic failure. Most often, the induction of enzymes occurs through the activation of nuclear receptors such as the Arylhydrocarbon receptor (Ahr), the Pregnane X receptor (PXR) and the constitutive Androstane Receptor (ACR). The activation of nuclear receptors PXR and CAR are responsible for the induction of several drug metabolizing enzymes including CYP3A, UGT1A1, SULT1A and CYP2C9. On the other hand, induction of CYP1A, SULT1A1 and UGT1A1 has been associated with activation of AhR. Prediction of Metabolic Stability As mentioned above, metabolic stability influences both oral bioavailability and half life of a drug. There is good correlation between in vitro metabolic stability and in vivo clearance. Therefore, the assessment of metabolic stability of compounds is being demanded and earlier in discovery projects. To meet these needs, in silico models are commonly employed. As described above, many different in silico tools focused on studying different aspects of metabolism have been developed. In our experience, the choice of the in silico tool by a user should primarily be guided by the type of information and level of accuracy that is desired. It is imperative that the developers of these in silico tools continually refine and validate them to reliably predict and quantify the metabolic fate of drug in humans. On the other hand, the chemists, biologists and ADME scientist on project teams to evaluate and use the existing in silico tools and to challenge their developers to demand tools that will rationally and efficiently move the discovery projects forward. Metabol Expert Metabol Expert is an ideal program for a quick prediction of the metabolic fate of compound in the drug discovery process during the dispositional research phase. Metabol Expert is a unique tool for initial estimation of the structural formula of metabolites. Metabol Expert is a rule based system with open architecture, in other words, the chemists, metabolism researchers, drug disposition experts and environmental managers can understand, expand, modify or optimize the data on which the metabolic structural estimation relies. Commercialized by Compudrug in 1987, Metabol Expert is composed of a database, a knowledge base and several prediction tools. The basic biotransformation database contains 179 biotransformations, 112 of which are derived from Testa and Jenner, the others are based on frequently occurring metabolic pathways. The transformation knowledge-base is composed of if-then type rules. Each is composed of our components, the structure changed during the transformation, the new substructure formed, a list of substructure at least one of which must be present in the molecule for the biotransformation form occurring. These rules have been derived from the literature by experts and are input into the system by means of graphical tools. The system is open so that new rules can be added or existing ones modified or deleted. There are two types of predictions in Metabol Expert. In the first type, the system tries to match basic transformations automatically. There is a filter so that biotransformation sequences can be arrested after generation of a specified number of metabolites. Basic transformations are classified as phase I or phase II. In the event of a phase II metabolite being generated, the sequences are arrested and the metabolite is not included in the next level. If a transformation results in the generation of two metabolites, then both are passed into the next level. The second type of analysis is an extended prediction model in which metabolites generated from basic transformations is compared to a list of transformations in a learned tree for a given species and the analogues are then listed in order of similarity. The program then attempts to quantify predictions based in the information in the learned tree. MexAlert MexAlert was developed to be an ideal assistant for high-throughput screening. It is advantageous to consider metabolism still before synthesis of the compounds, in order to exclude unwanted metabolic pathways, leading, for example, to first pass effect or to formation of toxic intermediates. MexAlert predicts first pass metabolic pathways by quickly identifying sites on the molecule where Phase II metabolic transformations (in other words, conjugation) may occur. It is rule based system; the rules are selected from among the Phase II transformations in the animal knowledge base, and modified according to in vivo experimental example of first-pass effect pathways. In silico toxicity prediction Attrition during the drug development process is a serious economic problem for the pharmaceutical industry and it is often due to inappropriate ADME/Tox characteristics. IT has been estimated that 20-40% of the drug failure in investigational drug development phases are due to safety issues, not continuing multiple incidents of adverse effects of existing drugs. The early drug discovery process needs to address in parallel not only potency but also pharmacokinetics and toxicological properties. Van de Waterbeemd and his colleagues at Pfizer have called this approach ‘property-based design’, emphasizing the importance of the critical combinations of physical and structural properties that contribute to ‘druglikeness’. Ideally this process should begin early in discovery, using computational models to screen both virtual libraries and available compound collections to identify compounds with the desired properties (good potency, ADME and low toxicity). Often molecular size and lipophilicity have an important effect on all three properties. High biological activity is frequently associated with high LogP, but this may also raise the probability of high toxicity. In the 1990s, drug companies invested heavily in combinatorial chemistry and high-throughput screening (HTS) as a source of leads for new targets. Most screen actives turned out to be large and/or hydrophobic, clearly contraindicating to the principles of minimal hydrophobicity. The most visible outcome was not even that they were toxic (because most compounds did not advance that far in development), but that they were either insoluble or non-absorbable. This overshadowed any toxicological consideration in the early stages of drug discovery, bringing forward compounds solubility and permeability as the most urgent problems to address. In the late 1990s the concepts of drug-likeness and lead likeness emerged and simple rules were formulated e.g. â€Å"rule of 5† to warn chemists when compounds were well outside the property space normal for orally active drugs. These rules are now widely used in Virtual Screening to remove undesirable compounds from consideration prior to their synthesis or acquisition. In addition to simple property filters toxicological issues should also be considered because otherwise any specific hazardous sub structural effects are ignored. Some of the harshest reactivity effects are identified and removed using predefined alert substructures (e.g., acid halides) (sometimes called â€Å"garbage filters†). The problem is the most of such alert substructures are â€Å"chameleonic† in nature, i.e., they may not necessarily cause toxic effects depending on other functional groups and overall molecular structures (e.g., acid halides). To fix this, all chameleonic† substructures (from â€Å"garbage† filters and beyond) must be supplemented with class specific QSAR’s for different health effects, yielding toxicological expert systems. Such systems can be used in virtual screening along with â€Å"drug –likeness† filters to subdivide compounds into â€Å"safe†, â€Å"hazardous† and â€Å"Questionable†. Promising compounds need further toxicological evaluation, but this cannot be done by predicative methods alone due to multiple knowledge gaps in their training sets and limited numbers of considered toxicological end points. Sometimes further evaluation is done during lead optimization, when chemical structures are covalently modified and tested. At this stage various toxicological predictions are used to prioritize both compounds that are to be tested and in vitro methods can reliably predict drug’s effect on a whole animal system, yet Animal Tests are not usually done until drug development candidates are identified. By this time drug development cost can reach substantial levels, economic risks become considerable. Thus any predictive tools that help to identify adverse effects in animals prior to conducting such testes are highly desirable. If a known toxic pharmacophore is identified and closely related to the pharmacophore required for activity at the therapeutic target then series specific SAR is needed to aid design of molecules with an adequate separation between the therapeutic dose and the dose threshold for the toxic effect. Since it is essential to have an in vitro surrogate that can model the desired in vivo effect on a significant number of compounds. Some of the more important end points for which in vitro surrogates that can model the desired in vivo effect on a significant numbers of compounds. Some of the more important end points for which in vitro surrogates have been used are: QT prolongation in heart due to blockade of the hERG potassium channel, hepatotoxicity due to compounds that produce phospholipidosis and hepatotoxicity due to induction of CYP450 enzymes. To summarize, in drug design toxicity predictions can be useful for three purpose – virtual screeing, prioritization of compounds and in vitro tests, and prediction of health effects in whole animal systems. Although many toxicologists are understandably leave us with no choice but to make the attempt using available animal toxicity database.

Humans Soon To Be Extinct :: essays research papers fc

Table of Contents Abstract.....................................page Body.........................................pages Bibliography.................................page Appendix.....................................pages Structured List.........................page Figures.................................page Figures.................................page Figures.................................page Figures.................................page Figures.................................page Figures.................................page Figures.................................page Abstract Ever since Dewey McLean (1978) proposed a dinosaur extinction theory that states that a climatic change killed the dinosaurs, it has become the single most accepted theory for the dinosaur extinctions within the scientific community. It is called the dinosaur- greenhouse extinction theory. It says that a climate change via the greenhouse effect killed off the dinosaurs. My paper takes this proposed theory and relates it to the world today. Some of the things that happened back then are also happening now, and if the dinosaur- greenhouse extinction theory is indeed true, then we are also in danger of dying from the greenhouse vertebrate killing mechanism, abrupt atmospheric changes, and the other effects caused by the increased greenhouse effect and people should know about the consequences of what we are doing to the earth. My paper examines the similarities occurring in the two time periods and the possible results that we may soon be facing in the very near future. I am hoping that exposure to the inevitable danger that we are soon going to be facing, will spark action and concern within whomever reads my paper. It is a problem that we all have tended to shrug off and not worry about, but if we don't start worrying about it soon, there will not be anyone around to worry about. The time for action is now. We may still be able to change the future. Humans Soon to Become Extinct? Can it be? Roughly sixty-five million years ago a tremendous extinction of global proportions hit the planet earth. This global extinction was so severe that it has defined the boundary between two periods of geologic history called the Cretaceous and the Tertiary periods. All but a few mammals on land and water became extinct. (McLean,1978,p.1) The best known of these extinct animals from this mass extinction are the huge and mighty dinosaurs. What killed them nobody really knows and probably will never know, but scientist haven't hesitated to theorize about it. There have been theories ranging from human involvement to disease to even aliens. However, of all the theories of the so called K-T extinctions, the single most accepted theory is called The Volcano Greenhouse Theory. This theory states that a chain of volcanoes in India, called "the Deccan Traps", released vast quantities of the greenhouse gas carbon dioxide into earth's atmosphere trapping heat from the sun, (McLean,1988,p.2) and turning earth's surface into "the hot, sterilizing, hell of a major greenhouse." (McLean 1981,p.1) If the dinosaurs did in fact die from the Volcano-Greenhouse theory, then we are also in danger of becoming extinct from the Vertebrate

Crossover Fashion Essay -- essays research papers

Men’s Fashion for Women and Vice Versa Civilizations as ancient as Jericho and as widespread as the Roman Empire have used clothing and jewelry as a form of nonverbal communication to indicate specific occupation, rank, gender, class, wealth, and group affiliation. These same material goods are used today for similar modes of communication. While some modern societies like the Taliban in Afghanistan make such distinctions with utmost conformity (the Taliban of Afghanistan) others like America have proven to be more dynamic. This dynamic nature can be seen in the emergence of crossover fashion within the last 80 years which has correlated with the changing role and social status of women in society. The effect of the gradual increase of power for women during the Industrial Revolution could be seen in the increase of crossover fashion. As a result, crossover fashion is dominate and socially acceptable in today’s society. From the 1700’s through the Industrial Revolution, regulating fashion was deemed as a way of preserving social and gender distinctions that were firmly established in the predominantly patriarchal society. During the 1850’s, the Victorian Era, there were strict guidelines on how people could behave and dress, and behaviors that they had to conform to their everyday lives. The rules were so strict that there were codes for how certain inanimate objects should be displayed; for example, table covers had to be long enough to cover the table’s legs because soci...